关键词：胆盐，胆盐水解酶，bsh益生菌，高胆固醇血症

对乳酸菌中胆盐水解酶研究现状进行分析，从编码基因、蛋白氨基酸结构以及酶与肠道间密切关系等方面入手，阐述了肠道益生菌通过胆盐水解酶对胆盐的水解，可以达到耐受肠道胆盐压力，增强细菌表面对体内免疫系统的抵抗能力建立长期感染，促进在高等动物肠道内细菌的定殖，降低血清胆固醇水平等作用，为最终治愈高胆固醇血症提供了良好的解决方案。

乳酸菌（Lactobacillus）是发酵糖类且主要产物为乳酸的一类无芽孢、革兰氏染色阳性细菌的总称。凡是能从葡萄糖或乳糖的发酵过程中产生乳酸的细菌统称为乳酸菌。是一种存在于人类体内的益生菌。乳酸菌可用于制造酸奶、乳酪、德国酸菜、啤酒、葡萄酒、泡菜、腌渍食品和其他发酵食品。

Research progress on rnechanisrn ofbile salt hydrolase in probioticsRENJing,WU Zheng-j un,WANG Yin-yu (Basic Research Department, Technical Center ofBright Dairy & Food Co. Ltd., Shanghai 200436, China)Abstract : Bile salt hydrolysis plays an important role in digestion of lipids and fat metabolism in vertebrates. We analyse the research progress ofbile salt hydrolase base on the works of coding sequences. structure of amino acids and relationship between bile salt hydrolase and intestine. It isshown that the intestinal microbiota can resistant the bile salt stress and increase the ability of resistance ofinnate immune system. This give a greathint that we can imagine the day hypercholesterolemia be cured and serum lipids are reduced bv intestinal microbiota colonization.Kev words : bile salt ; bile salt hydrolase ; bsh probiotics ; hypercholesterolemia。